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Silence Therapeutics shares start at Buy from Jefferies, reflecting strong clinical data

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On Monday, Silence Therapeutics (NASDAQ:SLN) received a positive outlook from Jefferies, as the firm initiated coverage on the biotechnology company’s stock with a Buy rating and a price target of $40.00. Jefferies highlighted the potential of the company’s lead siRNA candidate, which has shown significant efficacy in lowering Lp(a), a causal risk factor for cardiovascular disease, by more than 90%.

The analyst from Jefferies noted that key opinion leaders (KOLs) believe Silence Therapeutics’ siRNA candidate stands out due to its efficacy and the less frequent injections required compared to similar programs. This favorable profile positions the candidate to potentially tap into a market worth over $20 billion.

Additionally, the company’s second candidate for treating Polycythemia Vera (PV), a hematologic disease that affects approximately 100,000 patients in the United States, has demonstrated promising Phase 1 data. The ongoing progress and updates from both the Lp(a)-lowering program and the PV treatment are expected to act as near-term catalysts for the company throughout 2024.

The endorsement from Jefferies comes at a time when Silence Therapeutics is actively developing its pipeline. The company’s focus on RNA interference (RNAi) technology for the treatment of diseases with unmet medical needs has positioned it as a notable player in the biotech industry.

Investors and stakeholders in the biotechnology sector are keeping an eye on Silence Therapeutics as it advances its clinical programs. The company’s progress and potential market opportunities are anticipated to influence its stock performance in the near future.

In other recent news, Silence Therapeutics has made significant strides in the biotechnology sector with its drug development programs. The company reported positive trial results for zerlasiran and divesiran, prompting H.C. Wainwright and BMO Capital Markets to maintain their Buy and Outperform ratings respectively. The potential of these drugs to generate over $1 billion in annual revenue is seen as a key factor in these ratings.

Silence Therapeutics has also received a $2.0 million milestone payment from Hansoh Pharmaceutical Group Company Limited, marking the second milestone in their partnership to develop short interfering RNAs using Silence’s mRNAi GOLD™ platform. This financial boost signifies growth and progress in the firm’s research endeavors.

In terms of personnel changes, the company announced the retirement of board member Alistair Gray. Despite this change, the firm is expected to continue its development and potential commercialization of its therapies, backed by a robust financial position with over $200 million expected to last into 2026.

InvestingPro Insights

As Silence Therapeutics (NASDAQ:SLN) garners attention with a positive outlook from Jefferies, investors may find additional context through InvestingPro data and tips. With a market capitalization of $893.37 million and a high Price / Book multiple of 6.05 as of the last twelve months leading up to Q2 2024, the company is trading at a valuation that reflects investor optimism about its future prospects. Despite a notable year-over-year revenue decline of 37.44%, the company’s liquid assets surpass its short-term obligations, providing financial flexibility as it continues to develop its siRNA candidate and other clinical programs.

According to InvestingPro Tips, Silence Therapeutics holds more cash than debt, which is a positive sign for financial stability. However, analysts do not expect the company to be profitable this year, reflecting the typical high research and development costs associated with the biotech industry. This is underscored by the company’s negative return on assets of -28.51% in the same period. On the brighter side, the company has experienced a significant return over the last year, with a price total return of 124.59%, showcasing the market’s strong response to its potential.

For investors seeking a deeper dive into Silence Therapeutics’ financials and market performance, there are additional InvestingPro Tips available at https://www.investing.com/pro/SLN. These tips could provide further insights into the company’s valuation and potential investment risks and opportunities.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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Musk says Howard Lutnick would ‘enact change’ if chosen for US Treasury job

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WASHINGTON (Reuters) -Billionaire Elon Musk, an adviser to U.S. President-elect Donald Trump, said on Saturday that Cantor Fitzgerald CEO Howard Lutnick would “actually enact change” if chosen as U.S. Treasury secretary.

Trump has not announced his nominee for the role, but Lutnick and investor Scott Bessent are serious contenders for the job and sources familiar with his thinking say Trump has been wrestling with picking one of the two or considering another option. 

Musk said Bessent is “a business-as-usual choice.”

“Business-as-usual is driving America bankrupt, so we need change one way or another,” Musk said on X. “Would be interesting to hear more people weigh in on this for Trump to consider feedback.”

Musk has been increasingly influential in Trump’s inner circle and has been staying at the president-elect’s Mar-a-Lago club in Palm Beach, Florida, as Trump forms his incoming government.

At a gala event on Thursday night, Trump teased Musk about his ongoing post-election stay at Mar-a-Lago.

“I can’t get him out of here. He just loves this place. And I like having him here,” said Trump.

At the end of the event, Musk mounted the stage.

© Reuters. FILE PHOTO: Howard Lutnick, Chairman and CEO of Cantor Fitzgerald, gestures as he speaks during a rally for Republican presidential nominee and former U.S. President Donald Trump at Madison Square Garden, in New York, U.S., October 27, 2024. REUTERS/Andrew Kelly/File Photo

“The public has given us a mandate that could not be more clear. The people have spoken, the people want change,” he said.

Lutnick has been helping Trump with his transition efforts. He has praised the president-elect’s economic policies, including his use of tariffs.

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Russia cuts gas to Austria in payment dispute, keeps EU flows

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By Vladimir Soldatkin and Guy Faulconbridge

MOSCOW (Reuters) -Russia halted gas supplies to Austria on Saturday in a dispute over payments but was still pumping steady volumes to Europe via Ukraine after remaining buyers asked for more gas.

Russia, which before the Ukraine war was the biggest single supplier of to Europe, has lost almost all of its European customers as the EU tries to reduce its dependence and after the Nord Stream pipeline to Germany was blown up in 2022.

Now one of the last main Russian gas routes to Europe – the Soviet-era Urengoy-Pomary-Uzhgorod pipeline via Ukraine – is due to shut at the end of this year, as Kyiv does not want to extend a five-year transit agreement which brings northern Siberian gas to Slovakia, the Czech Republic and Austria.

Austria said on Friday that Moscow had informed it that the gas would be shut off following an arbitration award to OMV, Austria’s biggest energy supplier, over unfulfilled supplies to its German unit by Russia’s state firm Gazprom (MCX:).

On Saturday, Austria’s energy regulator E-Control said Gazprom’s deliveries to OMV had stopped at 6 a.m. (0500 GMT), adding that prices and supplies to Austrian customers were steady.

OMV is seeking to recover the 230 million euro ($242 million) damages, awarded during arbitration, from Gazprom by offsetting the claim against invoices for deliveries to Austria – essentially stopping some payments for gas supplied via Ukraine.

Gazprom declined to comment on the suspension of flows to Austria, but the Russian company said it would send 42.4 million cubic metres of gas to Europe via Ukraine on Saturday, the same volume as on Friday and during every other day in recent months.

Slovak state-owned firm SPP said it was still receiving gas from Russia and added others were buying more.

“The situation when a large consumer stopped taking gas from the east, but the same volume flows through the territory of Ukraine, shows that there is still great interest in this gas in Europe,” SPP said in a statement, without naming the other buyers.

OMV usually accounts for around 40% of Russian gas flows via Ukraine, or some 17 mcm per day.

Austrian grid operator AGGM said it was not currently substituting imports from Germany or Italy. Austria said earlier it had plentiful stocks to cover the shortfall.

GAS POLITICS

Chancellor Olaf Scholz spoke to President Vladimir Putin on Friday for the first time in nearly two years, as European leaders wait to hear Donald Trump’s ideas on ending the biggest land war in Europe since World War Two.

According to the Kremlin, Putin told Scholz that Russia had always fulfilled its contractual obligations for energy supplies and was “ready for mutually beneficial cooperation if the German side shows interest in this”.

Soviet and post-Soviet leaders spent half a century from the discovery of major Siberian gas deposits in the post-WW2 years building up an energy business which linked the Soviet Union, then Russia, and Germany, by far Europe’s biggest economy.

War, and explosions, have destroyed that link, damaging the economies of both countries.

At its peak, Russia was supplying 35% of Europe’s gas but since the war started in 2022 Gazprom has lost market share to Norway, the United States and Qatar.

The Yamal-Europe pipeline via Belarus was closed after a dispute, while Russia blamed the United States and Britain for the explosions under the Baltic Sea that closed the Nord Stream route.

Washington and London have denied they blew up the pipelines. The Wall Street Journal has reported Ukrainian officials were behind the attack. Kyiv has denied that.

Without Austria, significant Russian supplies will only go to two European countries, Hungary and Slovakia, in Hungary’s case via a pipeline running mostly through Turkey.

Russia shipped some 15 billion cubic metres of gas via Ukraine in 2023, about 8% of peak Russian gas flows to Europe via various routes in 2018-2019, according to data compiled by Reuters.

© Reuters. FILE PHOTO: Svobodny, Russia November 29, 2019. REUTERS/Maxim Shemetov.

In 2023, the Ukraine transit route met 65% of gas demand in Austria and its eastern neighbours Hungary and Slovakia, according to the International Energy Agency.

($1 = 0.9487 euros)

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In Georgian breakaway Abkhazia, protesters refuse to leave parliament

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MOSCOW (Reuters) -Protesters in Georgia’s Russia-backed breakaway region of Abkhazia declined on Saturday to leave the parliament building which they stormed the previous day, a departure proposed by the region’s president as a condition for resigning.

Protesters had occupied the parliament in protest at an investment agreement between the Black Sea region and Moscow.

Russian news agency RIA reported that President Aslan Bzhania had said on Saturday he would resign and hold a snap election once protesters vacated the parliament in Abkhazia’s capital Sukhumi, and proposed a vice-president as interim head of state.

“When they leave the building, I will write my resignation letter and in the new election we’ll see how much support they get,” RIA cited Bzhania as saying.

He said he planned to run in that election.

Bzhania, quoted by Russian news agencies, later told a government meeting held in his native coastal village of Tamysh, that order would be restored. He said protesters only controlled the parliament and government buildings they had occupied.

“The situation will stabilise, everything will return to a legal framework,” RIA news agency quoted him as saying. “We have a president, we have laws. We have a homeland that we all must serve.”

Abkhazia’s interior ministry and security service issued statements saying they would obey orders from the president.

Protesters said in a statement that the occupation was not against Abkhazia’s close ties with Russia, but accused Bzhania of “trying to use these relations for his own selfish interests (and) manipulating them for the sake of strengthening his regime”.

TASS news agency quoted a representative of the protesters, Adgur Ardzinba, as saying they would remain in place until the president resigned.

Moscow said on Friday it was following the “crisis situation” with concern and urged Russian citizens to avoid travel to Abkhazia.

© Reuters. FILE PHOTO: A general view shows the Black Sea port of Sukhumi (Sukhum), the capital of Georgia's breakaway region of Abkhazia September 8, 2024. REUTERS/Igor Onuchin/File Photo

Russia recognised Abkhazia and another breakaway region, South Ossetia, as independent states in 2008 after defeating Georgia in a five-day war. It maintains military bases in both regions and props up their economies.

Most of the world recognises Abkhazia as part of Georgia, from which it broke away during wars in the early 1990s.

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