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EU approves TEPKINLY for certain lymphoma treatments

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COPENHAGEN – The European Commission has granted conditional marketing authorization to Genmab (NASDAQ:) A/S’s TEPKINLY (epcoritamab), making it the first subcutaneous bispecific antibody approved in the European Union for monotherapy treatment of adult patients with relapsed or refractory (R/R) follicular lymphoma (FL) after at least two lines of systemic therapy. This approval also extends to the European Economic Area countries and Northern Ireland.

Follicular lymphoma, a typically slow-growing form of non-Hodgkin’s lymphoma, accounts for 20-30% of all non-Hodgkin’s lymphoma cases and is considered incurable with no standard third-line treatment. The authorization of TEPKINLY offers a new treatment option for patients who have exhausted other therapies and often face relapse.

The approval is based on data from the Phase 1/2 EPCORE NHL-1 clinical trial, which showed an overall response rate of 83% and a complete response rate of 63% in patients treated with TEPKINLY. At a median follow-up of 16.2 months, the median duration of response was 21.4 months, with the duration of complete response not yet reached. The trial also demonstrated a favorable safety profile, with the most common adverse reactions being cytokine release syndrome, injection site reactions, and fatigue.

Genmab, in partnership with AbbVie (NYSE:), is committed to further development of epcoritamab as a potential core therapy for B-cell malignancies. The companies plan to pursue additional international regulatory approvals for R/R FL and R/R diffuse large B-cell lymphoma (DLBCL) indications.

The approval has been welcomed by the lymphoma community, as it represents a significant advancement in the treatment options available for patients with this challenging form of cancer.

This news article is based on a press release statement from Genmab A/S, an international biotechnology company focused on developing innovative antibody therapeutics for cancer treatment. The information provided here is intended for general informational purposes and should not be considered as medical advice. The safety and efficacy of TEPKINLY for investigational uses have not been established. For detailed safety information, please refer to the full Summary of Product Characteristics or the prescribing information in your region.

In other recent news, Genmab A/S has reported a capital increase resulting from employee warrant exercises. This development is part of the company’s internal incentive programs aimed at retaining employees. The company has not disclosed the number of warrants exercised or the amount of capital raised. Genmab, known for its work in the development of antibody therapeutics, has also disclosed transactions with shares and linked securities by managerial employees and their closely associated persons.

In financial news, Genmab has reported strong financial results for the first half of 2024, with a significant revenue growth of 36% to over DKK 9.5 billion and a 29% increase in operating profit to DKK 2.4 billion. The company’s drugs, DARZALEX, KESIMPTA, and EPKINLY, have contributed significantly to these figures. Genmab has also completed the acquisition of ProfoundBio, which is expected to enhance its long-term growth potential.

Despite potential volatility in their tax rate due to the integration of ProfoundBio operations, Genmab anticipates this to normalize within 12 to 18 months. The company is not actively seeking a partner for acasunlimab but may consider regional partnerships in the future. These are among the recent developments at Genmab.

InvestingPro Insights

In light of Genmab A/S’s recent European Commission approval for TEPKINLY, the company’s financial health and stock performance become a focal point for investors. Genmab’s market capitalization stands at a robust 17.47 billion USD, reflecting investor confidence in the company’s value and growth potential. The company’s P/E ratio, a key indicator of investor expectations for earnings growth, is 21.76, aligning with industry standards and suggesting a balanced valuation relative to its earnings.

Significantly, Genmab holds more cash than debt on its balance sheet, a strong indicator of financial stability and an InvestingPro Tip that highlights the company’s solid liquidity position. This financial footing could be instrumental in supporting ongoing research and development efforts, such as the further development of epcoritamab for B-cell malignancies. Additionally, Genmab’s revenue growth over the last twelve months has been impressive at 17.19%, signaling a healthy increase in the company’s financial inflows, which is essential for fuelling its strategic initiatives.

Investors may also take note of another InvestingPro Tip: Genmab’s management has been actively engaging in share buybacks, a move that often reflects leadership’s belief in the company’s future prospects and can be seen as a positive sign for shareholders. For those looking to delve deeper into the company’s financials and stock performance, there are over 10 additional InvestingPro Tips available at https://www.investing.com/pro/GMAB, offering comprehensive insights into Genmab’s market position and future outlook.

With Genmab’s commitment to advancing cancer treatment and its strong financial metrics, the company appears well-positioned to navigate the competitive landscape of the biotechnology industry and deliver value to both patients and investors alike.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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Consumers Energy Expanding Community Solar Program with 30-Acre Solar Project in Jackson County

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JACKSON, Mich., Sept. 19, 2024 /PRNewswire/ — Consumers Energy plans to break ground next spring on Blackman Solar, a new 30-acre community solar array in its home Jackson County that will provide local clean energy to customers through its Solar Gardens program.

Consumers Energy this week received approval from Blackman Township for the community solar project, which is slated to start generating electricity by the end of 2025.

“Blackman Solar is a great example of a partnership with a community to develop a project that delivers reliable, clean energy as well as local tax and economic benefits,” said David Hicks. Consumers Energy’s vice president of renewable energy development. “We’re grateful for the reception we’ve received from Blackman Township leaders and are excited to continue developing solar projects like this on our path to a carbon-neutral electric grid.”

Blackman Solar will generate power for Consumers Energy’s Solar Gardens community solar program, in which customers choose to support new solar projects without having to own solar arrays.

The new community solar facility will be the fourth that Consumers Energy owns and operates, joining other Solar Gardens projects in Cadillac, at Western Michigan University and at Grand Valley State University. Blackman Solar will include nearly 5,000 solar panels and will generate up to 2.5 megawatts of renewable electricity for 2,500 future Solar Gardens customers.

Blackman Solar also will provide new capacity to expand Consumers Energy’s income-qualified Solar Gardens program MI Sunrise. MI Sunrise is an efficient, easy, cost-effective way for municipalities, nonprofits and tribal governments to deploy federal grant dollars, providing access to clean, reliable renewable energy and measurable financial benefits to offset energy bills.

“Blackman Solar will help meet increased demand for community solar and offers shared solar infrastructure, accessibility and inclusivity, as well as financial and environmental benefits for all customers,” Hicks said.

Consumers Energy is committed to Michigan’s clean energy future. The energy provider is closing its final three coal-burning units next summer, one of the nation’s most aggressive timetables. The company is developing solar projects as part of its Clean Energy Plan to be carbon-neutral by 2040.

Consumers Energy is Michigan’s largest energy provider, providing and/or electricity to 6.8 million of the state’s 10 million residents in all 68 Lower Peninsula counties. Consumers Energy’s Clean Energy Plan calls for eliminating coal as an energy source in 2025, achieving net-zero carbon emissions and meeting 90% of customers’ energy needs through clean sources, including wind and solar.

For more information about Consumers Energy, go to ConsumersEnergy.com.

Check out Consumers Energy on Social Media

Facebook (NASDAQ:): https://www.facebook.com/consumersenergymichigan
Twitter: https://twitter.com/consumersenergy
LinkedIn: https://linkedin.com/company/consumersenergy
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First Horizon Is Now the Official Bank of the Ragin’ Cajuns

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MEMPHIS, Tenn., Sept. 19, 2024 /PRNewswire/ — First Horizon (NYSE:) Corp. (NYSE: FHN or “First Horizon“) is proud to announce that First Horizon Bank is now the Official Bank of the  University of Louisiana at Lafayette  Ragin’ Cajuns.

This five-year agreement expands First Horizon’s long-term commitment to the University  and includes a Ragin’ Cajun Visa (NYSE:) Debit card, prominent in-venue signage, entertainment and hospitality opportunities along with participation in game day fan activations and experiences, including the new Cajun Village.

“This is an exciting time to expand our partnership with ULL and ULL athletics,” said Jerry Prejean, President of Acadiana for First Horizon. “With more than $2.5 million invested in recent years towards academic and athletic excellence, First Horizon is proud to deepen our relationship with the University and work together as two long-standing community leaders dedicated to making Acadiana a great place to call home.”

“As opportunities have grown for businesses to support Ragin’ Cajuns athletics, First Horizon Bank has been right there growing with us every step of the way,” adds Brian Bille, General Manager of LEARFIELD-based Ragin’ Cajuns Sports Properties. “Jerry’s commitment to our community has never wavered, and I’m excited to help First Horizon build affinity with our fans through this enhanced partnership, and encourage our fans to add the all-new Ragin’ Cajuns branded debit card to their wallet.”

About First Horizon  
First Horizon Corp. (NYSE: FHN), with $82.2 billion in assets as of June  30, 2024, is a leading regional financial services company, dedicated to helping our clients, communities and associates unlock their full potential with capital and counsel. Headquartered in Memphis, TN, the banking subsidiary First Horizon Bank operates in 12 states across the southern U.S. The Company and its subsidiaries offer commercial, private banking, consumer, small business, wealth and trust management, retail brokerage, capital markets, fixed income, and mortgage banking services. First Horizon has been recognized as one of the nation’s best employers by Fortune and Forbes magazines and a Top 10 Most Reputable U.S. Bank. More information is available at  www.FirstHorizon.com.

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Oil prices rise on easing demand worries after jumbo Fed rate cut

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Investing.com — Oil prices jumped Thursday, riding on a wave of risk-on sentiment as the Federal Reserve’s outsized interest rate cut on Wednesday eased worries that a slowing US economy would further dent crude demand.

At 2:06 p.m. ET (1906 GMT), rose 1.6% to $74.80 a barrel and rose 1.8% to $71.12 a barrel. 

Jobless claims rise by less than expected 

The number of Americans filing for first-time unemployment benefits rose by less than anticipated last week, with coming in at 219,000 in the week ended on Sept. 14, compared with an upwardly revised 231,000 in the prior week.

Economists had forecast a consensus figure of 230,000.

This figure was better than expected, and has allayed to a degree concerns over the health of the US economy, particularly after the Federal Reserve started its latest rate-cutting cycle on Wednesday, trimming interest rates for the first time since March 2020 by a hefty 50 basis points to a range of 4.75% to 5%.

While lower rates usually bode well for economic activity, the Fed’s aggressive cut sparked some concerns over a potential slowdown in economic growth. 

While Fed Chair Jerome Powell helped soothe some of these concerns, he also said that the Fed had no intention of returning to an era of ultra-low interest rates, and that the central bank’s neutral rate was likely to be much higher than seen in the past.

His comments indicated that while interest rates will fall in the near-term, the Fed was likely to keep rates higher in the medium-to-long term.

US inventories fall, but product stockpiles up 

Government data released on Wednesday showed a bigger-than-expected, 1.63 million barrel draw in .

While the draw was much bigger than expectations for a draw of 0.2 mb, it was also accompanied by builds in and inventories. 

The builds in product inventories sparked increased concerns that U.S. fuel demand was cooling as the travel-heavy summer season wound to a close. 

Looking ahead, some expect further draws in domestic crude stocks as exports reaccelerate. 

“We look for a significant rebound in exports across crude and products this week. Among products, our preliminary expectations point to draws in gasoline (-1.5 MM BBL) and distillate (-3.7 MM BBL) with a build in jet (+0.5 MM BBL),” Macquarie said in a recent note.

Crude deficit could boost Brent 

Still, prices could be bolstered in the near-term by demand possibly outstripping supply in the fourth quarter, according to analysts at Citi.

A reported decision by the Organization of the Petroleum Exporting Countries and its allies to delay the beginning of a tapering in voluntary output cuts, along with ongoing supply losses in Libya, is predicted to contribute to a oil market deficit of around 0.4 million barrels per day in the final three months of 2024, the Citi analysts said.

They added that such a trend could offer some temporary support to Brent “in the $70 to $75 per barrel range.”

Meanwhile, the benchmark could be further boosted by a potential rebound in recently tepid demand from top oil importer China, the analysts said.

But they flagged that they still anticipate “renewed price weakness” in 2025, with Brent on a path to $60 per barrel due to an impending surplus of one million barrels per day.

(Peter Nurse, Ambar Warrick contributed to this article.)

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